*Dates and locations subject to change.
| Date(s) | Time/Result | Matchup | Location |
| JANUARY | |||
| Friday, Jan. 30 | KC, 7-0 | Kansas City Wizards vs. U.S. U-17s | Bradenton, Fla. |
| FEBRUARY | |||
| Sunday, Feb. 1 | CHI, 5-0 | Chicago Fire vs. University of Central Florida | |
| Wednesday, Feb. 4 | KC, 3-2 | Kansas City Wizards vs. Chicago Fire | Bradenton, Fla. |
| Thursday, Feb. 5 | VEJ, 4-1 | D.C. United vs. Vejle Boldklub | IMG Academy, Bradenton, Fla. |
| Friday, Feb. 6 | HOU, 3-0 | Houston Dynamo vs. FC Dallas | Frisco, Texas |
| Saturday, Feb. 7 | Tie, 4-4 | Kansas City Wizards vs. New York Red Bulls | Bradenton, Fla. |
| Saturday, Feb. 7 | CHI, 1-0 | Chicago Fire vs. Puerto Rico Islanders | |
| Sunday, Feb. 8 | Tie, 0-0 | Real Salt Lake vs. Ventura County Fusion | |
| Monday, Feb. 9 | FCD, 0-0 | Houston Dynamo vs. FC Dallas | Pizza Hut Park, Frisco, Texas |
| Monday, Feb. 9 | SEA, 3-1 | Seattle Sounders FC vs. LA Galaxy | Home Depot Center, Field ˝ (Carson, Calif.) |
| Tuesday, Feb. 10 | CHI, 1-0 | Chicago Fire vs. Toronto FC | |
| Tuesday, Feb. 10 | D.C., 2-1 | D.C. United vs. Columbus Crew | Bradenton, Fla. |
| Tuesday, Feb. 10 | SEA, 2-0 | Seattle Sounders FC vs. Shandong Luneng | Oxnard College |
| Wednesday, Feb. 11 | SEA, 6-1 | Seattle Sounders FC vs. Fusion Buena High School | Ventura, Calif. |
| Thursday, Feb. 12 | COL, 3-0 | Colorado Rapids vs FIU | Sunrise, Fla. |
| Thursday, Feb. 12 | HOU, 2-0 | Houston Dynamo vs. LA Galaxy | Los Angeles, Calif. |
| Thursday, Feb. 12 | TAP, 3-1 | Chivas USA vs. Tapatio | Brazil/Mexico |
| Friday, Feb. 13 | SJ, 3-2 | San Jose Earthquakes vs. Seattle Sounders FC | Cal Poly (San Luis Obispo, Calif.) |
| Friday, Feb. 13 | RSL, 8-0 | Real Salt Lake vs Shandong Luneng Taishan | Ventura, Calif. |
| Friday, Feb. 13 | NY, 3-2 | Toronto FC vs. New York Red Bulls | IMG Academy (Bradenton, Fla.) |
| Saturday, Feb. 14 | FCD, 5-1 | FC Dallas vs. U. of Memphis | Pizza Hut Park, Frisco |
| Sunday, Feb. 15 | SJ, 2-0 | Houston Dynamo vs. San Jose Earthquakes | San Luis Obispo, Calif. |
| Tuesday, Feb. 17 | FCD, 1-0 | Colorado Rapids vs. FC Dallas | Sunrise, Fla. |
| Tuesday, Feb. 17 | CHV, 1-0 | Chivas USA vs TBD | Brazil/Mexico |
| Wednesday, Feb. 18 | Tie, 0-0 | Houston Dynamo vs. Hammarby IF | Los Angeles, Calif. |
| Wednesday, Feb. 18 | CLB, 2-0/6-0 | Columbus Crew vs. U. Tampa/Central Florida | Bradenton, Fla. |
| Wednesday, Feb. 18 | Tie, 1-1 | Chicago Fire vs. Queretaro | Queretaro, Mexico |
| Friday, Feb. 20 | SEA, 4-1 | Seattle Sounders FC vs. University of Portland | Merlo Field (Portland, Ore.) |
| Friday, Feb. 20 | SJ, 6-0 | San Jose Earthquakes vs. Fresno Fuego | Chukchansi Park (Fresno, Calif.) |
| Saturday, Feb. 21 | RSL, 2-0 | Real Salt Lake vs. South Florida | University of South Florida |
| Saturday, Feb. 21 | DC, 2-1 | D.C. United vs. Puerto Rico Islanders | Puerto Rico |
| Saturday, Feb. 21 | TFC, 3-0 | Toronto FC vs. Florida Atlantic | Lockhart Stadium (Sunrise, Fla.) |
| Saturday, Feb. 21 | CHV, 2-0 | Tie, 0-0 | Chivas USA vs. Hammarby / UCLA | Home Depot Center (Carson, Calif.) |
| Sunday, Feb. 22 | SEA, 4-0 | Seattle Sounders FC vs, Vancouver Whitecaps | Qwest Field (Seattle, Wash.) |
| Monday, Feb. 23 | KC, 3-0 | Kansas City Wizards vs. Atlas | Guadalajara, Mexico |
| Monday, Feb. 23 | TFC, 3-0 | Toronto FC vs. Hacken (Sweden) | Sunrise, Fla. |
| Tuesday, Feb. 24 | NY, 2-1 | New York Red Bulls vs. Velez Sarsfield | Argentina |
| Tuesday, Feb. 24 | RSL, 4-0 | Real Salt Lake vs. University of Tampa | University of Tampa |
| Thursday, Feb. 26 | Tie, 1-1 | Kansas City Wizards vs. CD Guadalajara reserves | Guadalajara, Mexico |
| Thursday, Feb. 26 | NY, 2-1 | New York Red Bulls vs. River Plate | Argentina |
| Friday, Feb. 27 | SJ, 2-0 | Colorado Rapids at San Jose Earthquakes | Buck Shaw Stadium |
| Friday, Feb. 27 | SEA, 3-1 | Seattle Sounders FC vs. Estudiantes | Buenos Aires, Argentina |
| Saturday, Feb. 28 | HOU, 3-2 | Houston Dynamo vs. Montreal Impact | Carl Lewis Track (Houston, Texas) |
| Saturday, Feb. 28 | Tie, 1-1 | Seattle Sounders FC vs. Rosario | Buenos Aires, Argentina |
| Saturday, Feb. 28 | NE, 2-0 | New England vs. Austin Aztex FC | Nelson Field, Austin, Texas |
| MARCH | |||
| Sunday, March 1 | CHV, 4-0 | Chivas USA vs. Ventura County Fusion | Santa Clarita, Calif. |
| Sunday, March 1 | CLB, 5-1 | Columbus Crew vs. Everton Reserves | |
| Monday, March 2 | COL, 2-1 | San Jose Earthquakes vs. Colorado Rapids | Home Depot Center (Carson, Calif.) |
| Monday, March 2 | PAR, 4-3 | FC Dallas vs. Parana | Curitiba, Brazil |
| Tuesday, March 3 | Tie, 1-1 | New York Red Bulls vs. Argentinos Juniors | Argentina |
| Tuesday, March 3 | SEA, 5-0 | Seattle Sounders FC vs. Tristán Suárez | Buenos Aires, Argentina |
| Wednesday, March 4 | CAP, 4-3 | FC Dallas vs. Clube Atletico Paranaense | Curitiba, Brazil |
| Wednesday, March 4 | SJ, 1-0 | Chivas USA vs. San Jose Earthquakes | Home Depot Center (Carson, Calif.) |
| Wednesday, March 4 | Tie, 0-0 | Kansas City Wizards vs. Salamanca | Guadalajara, Mexico |
| Wednesday, March 4 | COL, 5-2 | LA Galaxy vs. Colorado Rapids | University Field 1 (Carson, Calif.) |
| Thursday, March 5 | RP, 1-0 | Seattle Sounders FC vs. River Plate | Buenos Aires, Argentina |
| Thursday, March 5 | CLB, 2-0 | Columbus Crew vs. Liverpool Reserves | Liverpool academy, Knowsley, GBR |
| Saturday, March 7 | NE, 2-1 | New England Revolution vs. Wake Forest University | Macpherson Stadium (Greensboro, N.C.) |
| Saturday, March 7 | TFC, 2-1 | Toronto FC vs. Charleston Battery | Charleston, S.C. |
| Saturday, March 7 | RSL, 3-0 | D.C. United vs. Real Salt Lake | Charleston, S.C. |
| Saturday, March 7 | Tie, 2-2 | Houston Dynamo vs. Austin Aztex | Austin, Texas |
| Wednesday, March 11 | TFC, 2-1 | D.C. United vs. Toronto FC | Charleston, S.C. |
| Wednesday, March 11 | RSL, 2-1 | Real Salt Lake vs. Charleston | Charleston, S.C. |
| Wednesday, March 11 | CAL, 2-1 | San Jose Earthquakes at California | California |
| Thursday, March 12 | NY, 2-0 | New York Red Bulls vs. CPB | Baltimore, Md. |
| Thursday, March 12 | COL, 1-0 | Seattle Sounders FC vs. Colorado Rapids | Qwest field (Seattle, Wash.) |
| Saturday, March 14 | D.C., 2-0 | D.C. United vs. Charleston | Charleston, S.C. |
| Saturday, March 14 | FCD, 1-0 | FC Dallas vs. Clube Atletico Paranaense | Pizza Hut Park |
| Saturday, March 14 | Tie, 2-2 | Houston Dynamo vs. Chivas USA | |
| Saturday, March 14 | RSL, 2-1 | Toronto FC vs. Real Salt Lake | |
| Saturday, March 14 | Tie, 1-1 | LA Galaxy vs. Chicago Fire | Phoenix, Ariz. |
| Saturday, March 14 | AUS, 1-0 | Columbus Crew at Austin Aztex FC (USL-1) | |
| Saturday, March 14 | KC, 4-0 | Kansas City Wizards vs. Minnesota Thunder | |
| Saturday, March 14 | CAR, 1-0 | New England Revolution vs. Carolina Rail Hawks | WakeMed Stadium (Cary, N.C.) |
